Association between paraoxonase-1 (PON-1) polymorphisms and polycystic ovary syndrome susceptibility: a meta-analysis

Several investigations have focused on the relationship between paraoxonase-1 (PON-1) polymorphisms and the risk of polycystic ovary syndrome (PCOS); however, the result remains conflicting. To obtain a more precise estimation of the correlation between PON-1 polymorphisms [rs705379 C>T (-108C/T), rs854560 T>A (55Leu/ Met) and rs662 A>G (192Gln/Arg)] and the risk of PCOS, we performed a meta-analysis of 940 PCOS cases and 881 controls concerning rs705379 C>T polymorphism, 1,436 PCOS cases and 1,053 controls concerning rs854560 T>A polymorphism and 1,306 PCOS cases and 983 controls concerning rs662 A>G polymorphism from eight publications. The crude odds ratios (ORs) with 95% confidence intervals (CIs) were harnessed to measure the strength of the association. Our findings suggested that there was an evidence of a correlation between the PON-1 rs705379 C>T polymorphism and increased risk of PCOS in three genetic models: allelic comparison, homozygote comparison and recessive comparison. While the association between PON-1 rs854560 T>A polymorphism and a decreased risk of PCOS was found in dominant model. PON-1 rs662 A>G polymorphism is not correlated with PCOS susceptibility. In summary, this study suggests that PON-1 rs705379 C>T polymorphism may cause an increased risk of PCOS, while PON-1 rs854560 T>A polymorphism may cause a decreased risk of PCOS.